Wednesday, November 19, 2014

Evolution could be accelerated and influenced and the DNA is not just a piece of information

We all know that genes are responsible for the making, regulation and manipulation of an organism. Genes as represented by series of DNA or RNA are considered to have recorded and passed the influence of the environment to the next generation via mutation. It is not necessarily mutation that passes the gene manipulation to the next generation. Organisms can change their DNA according to the conditions that they are presented with. It is not a self controlled process but yet the gene pool of an organism could be altered without mutations.

The DNA of an organism is the blue print of its building up. As the embryo grows up, the new organism is formed. The DNA is mixed from paternal and maternal reproductive cells. It is not necessary to have fusion of male and female reproductive cells in order to mix the DNA. The process could also take place in ordinary cells.

There must be other cells that mix their DNA in the process of cell division and cell growth. The most probable candidates for DNA mix up could be the ones that are exposed to the environment. The cells of the epidermis of any organism or the cells that are in touch with the environment should show DNA mixing and splitting as they divide into many cells.

The change in the DNA in cells other than the gametocytes would not influence the current structure of the organism. The purpose or the product of the change in the DNA of other cells should be to pass the recorded information to the next generation of cells.

The gametocytes should represent the changes in somatic cell DNA in some way. The more similar changes take place in somatic cells would be represented in the making of the gametes.

I am not telling fairy tales, it is just that I don’t have the facilities to conduct experiments and prove my theories. So I propose the experiments for anyone to conduct and disprove before being skeptical.

Experiment:

A small multi cellular organism has to be selected for the experiment where the number of cells in that organism should be in the order of thousands. It will be easier to manipulate higher ratios of cells in the organisms in order to observe the results in the next generation.

Take only one male and one female organism but in two separate vessels. Insert any gene that could be recognized by its product; like the gene responsible for secreting insulin. The same technology that is used to commercially produce insulin through bacterial colonies could be used. The gene does not have to be inserted into the DNA of the somatic cells in the organism. Just introducing maximum quantity of genes into the medium should be enough for the genes to be taken into the organisms. The male and female organism will intake the genes but not into their DNAs. The introduced gene just has to be inside the somatic cells. The more number of cells intake the gene, the more the germ cells would respond to the presence of a foreign gene.

Once the genes have been taken into the organisms, the organisms should be transferred to fresh medium and into one vessel so that they can start reproducing. Now the medium will not have insulin genes but the somatic cells of the organisms will. In the resulting organisms ( the next generation ) there will be cells with insulin genes incorporated into their own DNA or genes related to the insulin genes (derivatives or deviations of the insulin gene).

A fine tuned experiment would be to insert the foreign genes into the somatic cells and not into the germ cells. This would be time consuming and extremely difficult as inserting DNA fragments separately into the somatic cells of a living organism might kill the organism; but if it could be performed, then the result would be fined tuned too.


Experiment 2:

Grafting of plants is another way to see the gene mixing in somatic cells. If you graft two species of plants that belong to the same genre or family, then you will have a zone where there are cells of both species present. This area will actually not hold just two different sets of genes. The cells in the transformation zone of the grafted area will hold thousand of different cells with entirely different genes. The transformation zone will have cells with the gene pools of the original two species and a number of transformational gene pools between the two species. If you can extract the cells at different parts of the grafted area and reproduce them into new plants through tissue culture, then the resulting plants will have both the original species and a number of new species formed. Some of them will be fertile and most of them would not be. These somatic cells would have the information recorded to affect the germ cells so that the germ cells would pass the information about the changes in the organism and the environment to the next generation of plants.

Also if you had two grafted plants and made them pollinate, the seeds produced will have the information about the grafting. In the siblings germinating from the seeds, there will be difference and correlation to the original two species used in the experiments.

-End of Experiments-

The representation of the conditions of the organism and its environment into the DNA of the somatic cells would have a probability. The representation of the changes in the DNA of the somatic cells into the DNA of the gametes would have another probability.

It is not fully conceivable to me to say which conditions would alter the DNA of the somatic cells and which ones at the somatic cells would be represented in the gametes. Important information will be carried out to the next generation. Important information for the existence of an organism or the continuation of a species is about the negative impacts more than favorable ones.

Prominent and negative environmental conditions that are experienced regularly by the organism would make changes in the DNA of the somatic cells. I am not talking about the X ray and other mutation causing high energy radiation.

I am talking about the less powerful but prominent conditions such as slightly increased temperature, higher concentration of Carbon Dioxide in the air or increased concentration of some particular micro nutrient in the soil around the roots.

Experiment:

If you take a plant species that reproduces rapidly through sexual reproduction and grow a colony of plants in ideal conditions for it, they will reproduce and will give regular offspring. If you keep all other conditions the same but increase the temperature of the environment by one degree Celsius, then there will be changes in the somatic cells and the changes will be represented in the gametes. The resulting offspring will have that information.

If the plant population is left in an isolated environment and left to reproduce generation after generation but exposed to the same increased temperature, the latest generations will have information about the environmental conditions and will start making adaptations to overcome the barrier.

(if the plant species selected is very smaller, and the reproductive duration is very smaller, then more generations will pass in shorter time period and the results could be seen quickly)

-End of experiment-

So, evolution would take place faster in organisms that grow up to reproductive age faster. And organism will evolve against difficult conditions and not along favorable conditions. Not all parts of the DNA produce amino acids or proteins. The majority of the DNA is junk (or at least is called the junk DNA). There is no need to keep the junk in each and every single cell in the organism. There is a cause and a purpose behind each and every single nitrogen base in the DNA.

The coding DNA is the confirmed and necessary commands for the making of the next generation of the organism and the blueprint of that particular species. The non coding DNA is the information about the conditions of the past organisms of the same species. It is the instruction manual for the germ cells to produce gametes that would abide by the needs of the species. The non coding DNA is the result of experience by the generations before the current one. The non coding DNA is there as a reference to the history of the species so that the germ cells would refer to their own non coding DNA and that of the somatic cells and would see if there are any differences. Differences that occurred similar to the ones occurred in the past could also be recognized from the pattern of the non coding DNA. Any new types of differences in the non coding DNA of the somatic cells would trigger adjustment of DNA in the gametes.

When chromosomes crossover to produce new combination of genes, they take reference from the non coding DNA in order to confirm where to split and where to join in meiosis.

Experiment:

Take a smaller and short living animal. Make a clone of that particular animal and introduce a foreign gene into the DNA of the stem cell of the clone. Insulin gene would be ideal. The cloned animal will have insulin genes in all the cells including the germ cells.

Make the animal mate with an animal of the opposite sex. The resulting offspring does not necessarily have to have insulin genes. Or the gametes don’t even have to have the insulin genes as they form. That is because the insulin genes are essentially part of coding DNA. This is not a reference to some change inside the organism or outside it. It will not affect the non coding DNA of the somatic cells. Hence, it will not be represented by the germ cells as a reference to a change. But, the germ cells will notice that the gene was not present in the past generations. This information is available in the non coding DNA of the germ cells. So the germ cells will either eliminate this unnecessary gene in the making of gametes or will make a note (produce a DNA series that records this change) in the non coding DNA of the gametes.

-End of experiment-

Experiment 2

If you could cut off the entire non coding DNA and have only the coding DNA of an organism, you could reproduce it asexually through mitosis. But the germ cells of that organism will be unable to produce gametes as they will miss the reference to make the gametes.

This could be performed in organisms that reproduce sexually and asexually.

-End of Experiment-

The DNA is the most sensitive sensor in the universe. It can sense each and every aspect of the entire environment. The making of the DNA is so precise that it resembles a resonating string, an energy wave with a particular wavelength and a regulated summation of information.

The design of the DNA makes it resonate and respond to resonations, vibrations, sounds, light and all forms of energy and other elements of the universe. A sound wave or an energy wave with the same wavelength of the DNA (the length of a turn at every 34 Angstroms) will have direct impact in the replication and manipulation of the DNA.

DNA is beyond the 3D wave form of sound and light. By the way that the DNA coils itself and onto the histone proteins, the DNA is not only a super coil, it also makes up a superwave that could align and conceive waves of multiple wavelengths and of multiple dimensions.

Double helix DNA could be able to conceive dimensions that are beyond consummation to equipments that man has made so far.

Experiment:

Take naked DNA in an appropriate vessel and expose it to 34 Angstrom wavelength of different sound and energy waves. The DNA will have direct effects to the waves such as vibrating, coiling, stretching, resonating, pulsing, capturing and releasing energy in sequences and or producing different forms of energy and sound, vibration or resonance.

Waves with the amplitude of one, two or multiples of two nanometers will have alignment of DNA double helix along the wave direction in addition to the effects proposed above.

A perfect and regular wave with 34 Angstrom wavelength and amplitude of one nanometer will have the DNA strand split as double helix and form a single helix.

-End of Experiment-

There is much to the DNA than just biology. DNA is the tool that the organisms have to conceive higher dimensions. As the body is filled with multiple numbers of the same DNA sequences, the sensing through DNA is like averaging trillions of readings for the same experiment to find the accurate reading. The precision and accuracy of the sensing are beyond comprehension and are not practical with any man made equipment.

If an energy wave passing through the human body is to be sensed with the DNA of all cells, then the accuracy of the sensing will be many numbers of times higher than advanced equipments used in advanced science laboratories today.

The mechanism through which the changes in the non coding DNA of the somatic cells are represented in the gametes is beyond my conception for the moment. DNA is not some inactive sequence of molecules that are used as a building guide for proteins. The DNA is very much active apart from its biological responsibilities. The DNA is able to sense and produce magnetic, electric and other fields. DNA can generate electricity. DNA can produce resonance, vibration and all forms of energy. DNA could sense temporal and spatial dimensions. DNA can format itself to be catalyst at different chemical reactions. The DNA is like an artificially intelligent information system that could perform on its own.


I will give a detailed explanation to the physical, chemical, spatial and temporal capacities of the DNA in a separate post.

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